Axillary lymph node dissection (ALND) had been the gold standard method to adequately determine the axillary stage in these patients.
#SENTINEL NODE BIOPSY FROZEN SECTION LICENSE#
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Īxillary lymph node status is one of the most important prognostic factors in breast carcinoma. Keywords: Breast cancer, sentinel lymph node biopsy, frozen section, micrometastasesĬopyright: © the authors licensee ecancermedicalscience. True-positive patients that were submitted to completion ALND had additional axillary lymph nodes with metastases in 28% of cases, whereas the group of false negatives had additional positive axillary lymph nodes in 40% of patients ( p = 0.62).Ĭonclusion: Frozen section analysis had a false-negative rate acceptable in SLN biopsy in our institution, and the micrometastasis in the SLN was the most important factor associated with the appearance of this phenomenon. The false-negative rate in SLN with macrometastasis was 13.1% and for micrometastasis cases was 66.7% ( p < 0.001). Results: A total of 281 patients were evaluated, identifying 18 cases with frozen section results as false negative (false-negative rate: 23.7%), and 55.5% of these cases were micrometastases. The histopathological findings were also evaluated in patients submitted to completion ALND. These results were compared to calculate the false-negative rate and the factors associated with it. Methods: We performed a five-year review of cases (2011–2015), including patients with early-stage breast cancer undergoing SLN biopsy, with frozen section evaluation and subsequent definitive pathological analysis. Secondarily, to evaluate the pathological results of cases submitted to completion axillary lymph node dissection (ALND) for positive SLN. Objective: To determine the false-negative rate, sensitivity, and diagnostic accuracy of the frozen section analysis of the sentinel lymph node (SLN) biopsy in early-stage breast cancer compared to the definitive section and to identify the factors that could be associated with the appearance of false-negative cases.
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